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January 2, 2024

Yotam Drier, PhD and Michal Rabani, PhD

Hebrew University of Jerusalem

ICRF Acceleration Grant

Enhancers control gene expression in DNA, the process in which the information included in a gene is turned into a functional product. They can produce RNA called eRNA, and a chemical change to eRNA, m6A, is essential to enhancer activity. In cancer, metabolic and genetic modifications can affect m6A levels in other types of RNA, but little is known about how this affects the m6A of eRNAs and disease development. Dr. Drier’s and Dr. Rabani’s investigation aims to determine which modifications contribute to cancer development. They plan to test potential treatments that can reverse these changes by targeting enhancers. 

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