Yitzhak Reizel, PhD

In the mammalian genome, the regions responsible for gene activity are subject to tight regulation. As an organism develops (organogenesis), each organ or cell type undergoes a specific program that enhances the accessibility of certain regions in the genome, which then regulate gene expression required for tissue development and maintenance. Pioneer factors enhance accessibility to these regions and trigger the developmental program of organ-specific genomic organization. By researching pioneer factor FoxA1, Dr. Reizel hopes to determine if normal organogenesis principles also regulate initiation and progression of cancer.

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