Nabieh Ayoub, PhD
Lung adenocarcinoma comprises some 40% of all lung-cancer cases, the leading cause of cancer deaths globally. The RBM10 gene, which has tumor-suppressor powers, is the most mutated gene in this cancer, with mutations evident in more than 20% of invasive tumors. There are 221 genes that, when inhibited, selectively eradicate lung adenocarcinomas in cells carrying RBM10 mutations. The Ayoub lab is focusing on one such gene, WEE1, to understand the molecular mechanisms that cause the death of RBM10-deficient lung adenocarcinoma cells.