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August 1, 2023

Naama Barkai, PhD

Weizmann Institute of Science

ICRF Project Grant

Histone chaperones are crucial to DNA-related processes and genome integrity. One chaperone, FACT, increases in tumor cells, where it correlates with tumor aggressiveness and poor prognosis. Tumor cells are more dependent on FACT than normal cells, and altering FACT levels leads to corresponding changes in tumor formation, a mechanism difficult to study with current technologies. The Barkai lab established a novel approach to overcome this methodological barrier, which may benefit new drug development.

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