Aaron Ciechanover, MD, DSc

In molecular biology and genetics, transcriptional regulation is how a cell regulates the conversion of DNA to RNA, thereby orchestrating genetic activity. The NF-kappaB protein is a key transcriptional regulator involved in many tumor types. The Ciechanover lab is working to unravel the mechanisms by which this “Mr. Hyde of inflammation and carcinogenesis” becomes Dr. Jekyll, a strong tumor suppressor.