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October 3, 2022

Yoav Shaul, PhD

Hebrew University-Hadassah Medical School

ICRF Project Grant Recipient

Yoav Shaul, PhD of Hebrew University/Hadassah Medical School, is the recipient of a new ICRF Project Grant. (This new grant continues his work after completion of an RCDA.) One of the major causes of breast cancer mortality is metastasis, when cells migrate from the primary tumor site to critical organs, such as the lungs. In his previously-funded research, Dr. Shaul discovered a specific enzyme, DPYD, which plays an essential role in the ability of breast cancer cells to metastasize. The goal of this project is to formulate a strategy to reduce DPYD accumulation by treating tumor cells with drugs. This is predicted to block metastasis and facilitate therapy of breast cancer.

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