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February 1, 2022

Reuven Wiener, PhD

Hebrew University

ICRF Project Grant Recipient

Reuven Wiener, PhD of Hebrew University of Jerusalem, received an ICRF Project Grant for his project entitled, “Mechanistic Understanding of Ufmylation for Anti-Cancer Drug Development.” Proteins are the workhorses of the cell and are responsible for almost all cellular processes. One protein that has been closely linked to cancer is UFM1. Improper regulation of protein modification by UFM1 (ufmylation) has been linked to several types of cancers, including breast, ovarian, and gastric cancers. The Wiener lab uses advanced methods for analysis of protein structure and activity in order to uncover the mechanisms by which UFM1 is attached to its target proteins, with the goal of making this pathway the target for novel anti-cancer drugs.

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