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July 29, 2022

Naama Barkai, PhD

Weizmann Institute of Science

ICRF Project Grant Recipient

Dr. Naama Barkai’s research at the Weizmann Institute of Science focuses on revealing general design principles that guide the function and evolution of biochemical circuits in normal and cancer cells. 

Dr. Barkai’s laboratory has recently established a novel approach that overcomes this methodological barrier. In this project, with the support of an ICRF Project Grant, she proposes to use this method to follow the consequences of FACT depletion and replenishment on the dynamic interactions of histones throughout the human genome. FACT function will be linked to specific histone interactions by analyzing appropriate mutants, establishing a link between the structure of FACT and its activities that will reveal the mechanistic basis of its action within cells. The results of this research may benefit future drug development efforts that target this oncogenic factor.

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