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January 31, 2023

Gil Ast, PhD

Tel Aviv University

ICRF Project Grant Recipient

Gil Ast, PhD, of Tel Aviv University is also a recipient of an ICRF Project Grant. DNA splicing is a key regulatory mechanism that can determine what proteins are made when, and how much is produced. This process is disturbed in many genetic diseases and in some cancers. Professor Ast seeks to understand how DNA is organized within the nucleus of a cell, which must convert DNA to the precise RNA molecule needed to produce the protein required by the cell. A better understanding of this process may ultimately lead to targeted cancer therapies of increased efficacy and decreased side effects.

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